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They act through TNF receptors type I (TNFRI) and type II (TNFRII), present on almost all cells except erythrocytes

Pollock S, Taylor S, Oyerinde O, et al.: The dark side of skin lightening: an international collaboration and review of a public health issue affecting dermatology

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131 The production of RONS increases the sensitivity of cells to genotoxic drugs by decreasing the activity of DNA-PKcs, hindering repair processes, and leading to the accumulation of DSBs

Cisplatin treatment was for 48 hours or 72 hours